Flavonoids – Small Molecules, High Hopes

small science , big hopes

A images of tumor cells being vaporized in beams of colorful light, a video produced by the National Cancer Institute proclaims, “the science is at our fingertips.” The science being referred to, which is 80,000 times smaller than the breadth of a single ridge of skin on a human fingertip, is cancer nanotechnology. Nanotechnology, the study of science on a level the width of ten hydrogen atoms,...

High Hopes and Disappointment

We study preferences for which choosing high expectations about the future make us happy now but make us unhappy later if they are not realized. These preferences generalize the recursive utility of Kreps-Porteus and Epstein-Zin. Like recursive utility agents, our agents care about the time resolution of uncertainty, but our agents are not purely forward-looking. For example, two agents with th...

New hopes from old drugs: revisiting DNA-binding small molecules as anticancer agents.

Most of the anticancer chemotherapeutic drugs that are broadly and successfully used today are DNA-damaging agents. Targeting of DNA has been proven to cause relatively potent and selective destruction of tumor cells. However, the clinical potential of DNA-damaging agents is limited by the adverse side effects and increased risk of secondary cancers that are consequences of the agents' genotoxi...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Biologics in the pipeline: large molecules with high hopes or bigger risks?

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